Effective drug-allergy checking: methodological and operational issues

Treatment non-response in OCD: methodological issues and operational definitions.

While controlled trials with SRIs have demonstrated a selective efficacy in obsessive-compulsive disorder (OCD), up to 40-60% of patients do not have a satisfactory outcome. Non-response to treatment in OCD is associated with serious social disability. There are a large number of non-responsive patients, and they are difficult to cluster due to ambiguities in the diagnostic criteria, possibilit...

Methodological issues in current antipsychotic drug trials.

Every year numerous reports on antipsychotic drug trials are being published in neuropsychiatric journals, adding new information to our knowledge in the field. The information however is often hard for the reader to interpret, sometimes contradictory to comparable available studies and leaves more questions open than it actually answers. Although the overall quality of the studies is rather go...

Methodological and Conceptual Issues in Understanding Female Hispanic Drug Users

This chapter has two main objectives. First, it briefly describes the methodological limitations evidenced in the research on female Hispanic drug users. Second, it proposes a conceptual framework that stimulates the discussion of constructs needed to understand drug use behavior and its consequences among Latinas. An attempt is made to examine multivariate influences on drug use and related pr...

Medical databases in studies of drug teratogenicity: methodological issues

More than half of all pregnant women take prescription medications, raising concerns about fetal safety. Medical databases routinely collecting data from large populations are potentially valuable resources for cohort studies addressing teratogenicity of drugs. These include electronic medical records, administrative databases, population health registries, and teratogenicity information servic...

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